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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ROCK2
All Species:
30.3
Human Site:
S550
Identified Species:
55.56
UniProt:
O75116
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75116
NP_004841.2
1388
160900
S550
L
K
K
R
N
Q
N
S
Q
I
S
T
E
K
V
Chimpanzee
Pan troglodytes
P61584
1003
117506
E300
N
L
E
K
V
E
G
E
R
K
E
A
Q
D
M
Rhesus Macaque
Macaca mulatta
XP_001096931
1524
173861
S686
L
K
K
R
N
Q
N
S
Q
I
S
T
E
K
V
Dog
Lupus familis
XP_540083
1519
175559
S681
L
K
K
R
N
Q
N
S
Q
I
S
T
E
K
V
Cat
Felis silvestris
Mouse
Mus musculus
P70336
1388
160567
S550
L
K
K
R
N
Q
S
S
Q
I
S
T
E
K
V
Rat
Rattus norvegicus
Q62868
1379
159417
S541
L
K
K
R
N
Q
S
S
Q
I
S
T
E
K
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505615
1400
161955
D493
A
K
L
K
L
E
K
D
F
I
N
L
Q
S
A
Chicken
Gallus gallus
XP_419954
1438
166280
S600
L
K
K
R
N
Q
N
S
Q
I
S
N
E
K
I
Frog
Xenopus laevis
NP_001154860
1372
159002
S536
L
E
R
R
N
Q
N
S
Q
I
S
N
E
K
M
Zebra Danio
Brachydanio rerio
NP_777288
1375
159755
S536
M
K
K
K
N
Q
N
S
H
I
S
N
E
K
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9W1B0
1637
186706
L565
A
M
Q
K
N
D
S
L
R
N
E
L
R
K
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P92199
1173
135756
A469
I
A
R
N
E
I
R
A
K
M
I
E
N
E
K
Sea Urchin
Strong. purpuratus
XP_001198244
1323
154677
L502
M
E
R
E
L
K
E
L
K
L
R
S
E
K
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
43.3
90.4
87.8
N.A.
96.6
95.7
N.A.
82.3
86.8
82
75.2
N.A.
24.1
N.A.
34.2
47.4
Protein Similarity:
100
56.9
90.8
89.5
N.A.
98.3
97.4
N.A.
86.2
91.9
89.9
86.6
N.A.
45.2
N.A.
52.8
64.9
P-Site Identity:
100
0
100
100
N.A.
93.3
93.3
N.A.
13.3
86.6
73.3
66.6
N.A.
13.3
N.A.
0
13.3
P-Site Similarity:
100
40
100
100
N.A.
100
100
N.A.
40
93.3
93.3
80
N.A.
40
N.A.
40
60
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
16
8
0
0
0
0
0
8
0
0
0
8
0
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
8
0
8
0
0
0
0
0
8
0
% D
% Glu:
0
16
8
8
8
16
8
8
0
0
16
8
70
8
0
% E
% Phe:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% H
% Ile:
8
0
0
0
0
8
0
0
0
70
8
0
0
0
8
% I
% Lys:
0
62
54
31
0
8
8
0
16
8
0
0
0
77
8
% K
% Leu:
54
8
8
0
16
0
0
16
0
8
0
16
0
0
0
% L
% Met:
16
8
0
0
0
0
0
0
0
8
0
0
0
0
16
% M
% Asn:
8
0
0
8
70
0
47
0
0
8
8
24
8
0
8
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
8
0
0
62
0
0
54
0
0
0
16
0
0
% Q
% Arg:
0
0
24
54
0
0
8
0
16
0
8
0
8
0
0
% R
% Ser:
0
0
0
0
0
0
24
62
0
0
62
8
0
8
8
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
39
0
0
8
% T
% Val:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
39
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _